Patient Education Blog

Eliquis (Apixaban) – Good News

Eliquis (Apixaban) is one of the 4 promising new oral “blood thinners” that (a) do not require monitoring of its “blood thinning” (anticoagulant) effect, i.e. do not require INR monitoring, and (b) do not interfere with vitamin K in the diet, i.e. patients can eat what they want. It is not available in the US at this point for any indication. The other 3 big drugs in this field are Pradaxa (=Dabigatran), Xarelto (= Rivaroxaban, and Savaysa (=Edoxaban).

The Good News

Good news on Aug 28th: The large atrial fibrillation trial – ARISTOTLE – was published today in the New England Journal of Medicine. A newer Clot Connect blog entry (link here) discusses these developments.

DVT and PE

What does this mean for the patient with DVT and PE?  The two major trials that investigate Eliquis in the treatment of DVT and PE are presently still ongoing:

  • AMPLIFY study (ClinicalTrials.gov identifier: NCT00643201): This study is ongoing and enrolling several thousand patients with acute DVT or PE. Patients either receive traditional treatment (low molecular weight heparin injections followed by warfarin) or Eliquis (Apixaban) for 6 months. Completion of the study is anticipated by Dec 2012.
  • AMPLIFY-EXT study (ClinicalTrials.gov identifier: NCT00633893): Once a patient has completed the regular/traditional several months’ treatment for an episode of DVT or PE, the patient gets enrolled into this “extension” trial and either receives Apixaban or placebo, given for 12 months. In medical terms this is called a secondary prevention trial. Completion of the study is anticipated by April 2013.

So, development of this promising drug is nicely moving forward. But the drug is still a few months away from potentially coming onto the market for patients with atrial fibrillation; and how Eliquis performs in patients with DVT and PE is still being investigated.

Disclosure:  I have no financial conflict of interest relevant to this educational post.

Last updated:  Aug 28th, 2011

Disclaimer:  ClotConnect.org, its contributors, authors, advisors, members and affiliate organizations do not assume any liability for the content of the website, blog and educational materials. Medical information changes rapidly. While information is believed to be correct, no representation is made and no responsibility is assumed for the accuracy of information contained on or available through this web site and blog. Information is subject to change without notice. 

Tags: , , , ,

5 Responses to “Eliquis (Apixaban) – Good News”

  1. LInda Miller says:

    I have Factor V Leiden as does my mom. More than likely her parents had it too and even great grandma. I developed a blood clot in 2009 after a flight from Israel. It was not a DVT…just thrombosis. My doctor says that I should be on warfarin the rest of my life. I am 55 now.

    • Stephan Moll says:

      Typically, a long distance airline associated clot (DVT or PE) would be treated with 3 months of blood thinners. However, it is unclear what the “thrombosis” mentioned above really describes: was it a superficial thrombophlebitis? In that case blood thinners are often given for only a few weeks. However, for a more complete assessment one would also want to know things like (a) is the “factor V Leiden” mentioned above heterozygous or homozygous factor V Leiden (i.e. does the person have one or two variant genes)?, (b) is there a family history of clots, (c) what are the person’s other risk factors for clots? These issues are discussed more in detail in the Clot Connect blog entry http://clotconnect.wordpress.com/2011/03/30/dvt-and-pe-how-long-to-treat-with-%E2%80%9Cblood-thinners%E2%80%9D.

  2. steve e hromjak says:

    This sounds very interesting to me. I was a good athlete all may life and still ride my bike. I have irregular heart beat and need blood thinners. I am proud to say I made the usa olympic team 1952 Helsinki, Finland. steve hromjak