Patient Education Blog

Archive for the ‘Blood thinners (anticoagulants)’ Category

New Publication: Eliquis (Apixaban) is Effective and Safe in DVT and PE

| Deep vein thrombosis (DVT), Eliquis - Apixaban, Pulmonary embolism, Trials, Venous clots | Comments Off on New Publication: Eliquis (Apixaban) is Effective and Safe in DVT and PE

Stephan Moll, MD writes…

An important study (called AMPLIFY trial) was published today in the New England Journal of Medicine [ref 1].  In a large study of patients with acute DVT or PE, Eliquis (apixaban) was as effective as warfarin and caused less major bleeding. Read the rest of this entry »

Reversal Agent for Eliquis – Early Clinical Study Results

| Eliquis - Apixaban | Comments Off on Reversal Agent for Eliquis – Early Clinical Study Results

Stephan Moll, MD writes….

The pharmaceutical company Portola reported today (May 8th, 2013) on the findings of their human volunteer study of their blood thinner antidote PRT4445 (ClinicalTrials.gov Identifier: NCT01758432  – medical details of the study design are here, study NCT01758432.  This dug is in early development.  In the study, healthy volunteers who had taken the new oral blood thinner Eliquis (Apixaban) received the reversal agent.  The study showed a “rapid and sustained and dose-related reversal” of the blood thinning effect of Eliquis” and “no serious adverse events”. Read the rest of this entry »

Natural supplements, herbs, vitamins and food: do any prevent blood clots?

| Blood thinners (anticoagulants), Herbal remedies, Prevention, Therapy, Uncategorized | Comments Off on Natural supplements, herbs, vitamins and food: do any prevent blood clots?

Beth Waldron, Clot Connect Program Director and Stephan Moll, MD, Clot Connect Medical Director write….

Patients who have ended their recommended course of prescription anticoagulation treatment are understandably concerned about a clot recurrence and will ask “is there anything I can do to prevent a future clot?” Some have heard from friends or the internet that a particular herb, vitamin, or food will aid in the prevention of DVT and PE.

Since more than half of adults in the United States take a dietary supplement of some kind, it may be helpful to examine the science behind some of the most common natural supplements and foods said to prevent blood clots.[1] Read the rest of this entry »

Top clinically relevant publications for patients from 2012

| Blood thinners (anticoagulants), Prevention, Therapy | Comments Off on Top clinically relevant publications for patients from 2012

Beth Waldron and Stephan Moll, MD write….

While much is known about blood clots and clotting disorders, there is still much being learnt.  Medical information changes over time as new clinical trials, research studies and evidence-based guidelines contribute to knowledge of and treatments for blood clots and clotting disorders.  Many of today’s standards of treatment are based upon what was learned from publications in the past.

Over the past year, a number of publications emerged which will influence future clinical decisions and potentially impact your care. Here is a summary of the ‘top clinically relevant publications from 2012’ and how they may affect you. Read the rest of this entry »

Eliquis (Apixaban) – What Your Physician Wants to Know

| Blood thinners (anticoagulants), Eliquis - Apixaban, Therapy | Comments Off on Eliquis (Apixaban) – What Your Physician Wants to Know

Stephan Moll, MD writes…

Apixaban (Eliquis) is one of the 3 new oral blood thinners. It is NOT approved at this point to prevent or treat  DVT or PE (also referred to as venous thromboembolism or VTE).  It is, however, FDA-approved for the use in patients with irregular heart beat (atrial fibrillation) to prevent stroke.  As the studies on VTE have not been completed and as the drug is not FDA-approved for VTE, I would NOT use it off label in patients with VTE.  However, for the health care professionals who prescribes apixaban for atrial fibrillation, we have made available the apixaban guideline (here) Read the rest of this entry »

Xarelto – What Your Physician Wants to Know

| Blood thinners (anticoagulants), Therapy, Xarelto - Rivaroxaban | Comments Off on Xarelto – What Your Physician Wants to Know

Stephan Moll, MD writes…

If you are considering to start therapy with the new oral “blood thinner” Xarelto (Rivaroxaban), there are a few safety nets that your local hospital and physician may want to establish to make therapy as safe as possible for you.  Issues to be addressed are (a) dosing, (b) management of major bleeding, (c) interruption of therapy for surgery, dental procedures, and other procedures, and d) what to do if you missed a dose.

These issues are probably best addressed by the establishment of a treatment algorithm/guide for the entire hospital or physician practice. Read the rest of this entry »

New Blood Thinner (Eliquis = Apixaban) FDA Approved

| Blood thinners (anticoagulants), Eliquis - Apixaban, Therapy | Comments Off on New Blood Thinner (Eliquis = Apixaban) FDA Approved

Stephan Moll, MD writes…  Another new oral blood thinner (Eliquis = apixaban) was approved by the FDA on Dec 28th, 2012 – to be used by patients with irregular heart beat (atrial fibrillation) to prevent stroke.  The drug is NOT yet FDA-approved for treatment of patients with DVT or PE.  Clinical trials evaluating Eliquis for this indication are still ongoing. Read the rest of this entry »

Behind the headlines: Does grapefruit interact with Xarelto (rivaroxaban)?

| Uncategorized, Xarelto - Rivaroxaban | Comments Off on Behind the headlines: Does grapefruit interact with Xarelto (rivaroxaban)?

Ref 1 News and Observer p 5B 12-17-2012

Beth Waldron, Program Director of Clot Connect, writes….

The claim:   In a recent newspaper article (ref 1), it was stated that “grapefruit eaten in ordinary amounts can interact harmfully with some common prescription drugs”.  Among the drugs listed is the oral anticoagulant Xarelto® (rivaroxaban). Read the rest of this entry »