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Posts Tagged ‘UNC’

Major Bleeding on Blood Thinners: Practical Guideline

| Bleeding, Blood thinners (anticoagulants) | Comments Off on Major Bleeding on Blood Thinners: Practical Guideline

Stephan Moll, MD writes…  Major bleeds on blood thinners (such as Coumadin, Jantoven, Eliquis, Pradaxa, Xarelto) and anti-platelet drugs (like aspirin, Plavix, Brilinta, Effient, etc.) occur every so often.  Quick action in Emergency Departments is needed in case of such bleeds.  Our medical center (University of North Carolina Hospitals,  Chapel Hill) has put together an “Emergent Anticoagulation Reversal Guideline” for our local use as a practical, clinical how-to document (PDF here).  Since not every medical institution has pharmacists and MDs with clotting expertise available to develop its own guideline, we are making this document available through Clot Connect and invite colleagues and hospitals  to take the document if they like, modify it, and apply it to their institution.


Disclosures:  I have been a consultant for CSL Behring and Janssen.

Last updated: June 9th, 2014

Eliquis (Apixaban) – What Your Physician Wants to Know

| Blood thinners (anticoagulants), Eliquis - Apixaban, Therapy | Comments Off on Eliquis (Apixaban) – What Your Physician Wants to Know

Stephan Moll, MD writes…

Apixaban (Eliquis) is one of the 3 new oral blood thinners. It is NOT approved at this point to prevent or treat  DVT or PE (also referred to as venous thromboembolism or VTE).  It is, however, FDA-approved for the use in patients with irregular heart beat (atrial fibrillation) to prevent stroke.  As the studies on VTE have not been completed and as the drug is not FDA-approved for VTE, I would NOT use it off label in patients with VTE.  However, for the health care professionals who prescribes apixaban for atrial fibrillation, we have made available the apixaban guideline (here) Read the rest of this entry »

Pradaxa – What Your Physician/Hospital Wants to Know

| Blood thinners (anticoagulants), Pradaxa - dabigatran | 4 Comments »

If you are considering to start therapy with the new oral “blood thinner” Pradaxa®, there are a few safety nets that your local hospital and physician may want to establish to make therapy as safe as possible for you. Issues to be addressed are (a) dosing, (b) management of major bleeding, (c) interruption of therapy for surgery, dental procedures, or other procedures, d) what to do if you missed a dose, and (e) what to do if the pill box has been left open for too long.

These issues are probably best addressed by the establishment of a treatment algorithm/guide/help for the whole hospital or physician practice.  As an example, attachedthat we developed for our institution, the University of North Carolina (UNC) Health Care System. Your physicians and pharmacists are free to (a) take the document and modify it to fit their institution/practice or (b) use it as a clinical reference for management issues.

Support Forum:  Questions or comments about Pradaxa and its use? Go to the online Clot Connect Support Forum, category “Anticoagulant Use (Blood Thinners)”.

For Health Care Professionals:  This same post, written for health care professionals, is posted here.

Disclosure: I have no financial conflict of interest relevant to this educational post.

Last updated: May 1st, 2012

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